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Benproperine

Alternative Names: benproperine
Latest Update: 2023-10-16
Latest Update Note: PubMed Publication

Product Description

Benproperine (Cofrel) is a cough suppressant. It is used for symptomatic relief of cough. It acts peripherally by blocking afferent sensory nerve impulses originating from receptors in the lungs and pleura. (Sourced from: https://drugs.ncats.io/drug/3AA6IZ48YK)

Mechanisms of Action: ARPC2 Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: China | Egypt | Hong Kong | Korea | Peru | Taiwan

Approved Indications: None

Known Adverse Events: None

Company: Huazhong Pharmaceutical
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Benproperine

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
CTR20211480

N/A

Not yet recruiting

Bronchitis, Chronic|Chronic Cough

None

CTR20202444

N/A

Active, not recruiting

Tobacco Use Disorder|Bronchitis|Inflammation|Rhinitis|Pharyngitis|Respiratory Tract Infections

None

CTR20211205

N/A

Not yet recruiting

Bronchitis, Chronic|Chronic Cough

None

Recent News Events

Date

Type

Title

10/16/2023

PubMed

 Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis.

03/26/2023

PubMed

 Comparison of Plasma Metabolome Response to Diets Enriched in Soybean and Partially-Hydrogenated Soybean Oil in Moderately Hypercholesterolemic Adults-A Pilot Study.

11/25/2022

PubMed

 S-Benproperine, an Active Stereoisomer of Benproperine, Suppresses Cancer Migration and Tumor Metastasis by Targeting ARPC2.

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