Product Description
Avotermin, the first agent identified in this class, is the clinical application of human recombinant transforming growth factor beta3 (TGFbeta3), a key protein involved in scar-free healing observed in embryos. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/18757391/)
Mechanisms of Action: TGFR Inhibitor
Novel Mechanism: No
Modality: Coagulation Factor
Route of Administration: Topical, Injection
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Renovo
Company Location:
Company CEO:
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 3: Depressive Disorder|Vision, Low
Phase 2: Healthy Volunteers|Injuries/wounds Unspecified|Keloid|Vision, Low|Nevus|Varicose Veins|Burns Unspecified
Phase 1: Healthy Volunteers|Lymphoma|Injuries/wounds Unspecified
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|
| RN1001-0098 | N/A |
Withdrawn |
Injuries/wounds Unspecified |
2010-03-01 |
2019-03-18 |
Treatments |
|
| KOHDIAK | P1 |
Not yet recruiting |
Lymphoma |
2021-02-01 |
|||
| RN1006 | P1 |
Completed |
Healthy Volunteers |
2010-09-01 |
2019-03-19 |
Treatments |
|
| Juvista | P1 |
Completed |
Healthy Volunteers|Injuries/wounds Unspecified |
2001-08-01 |
2019-03-19 |
Treatments |
|
| Juvista in the prevention or reduction of the resultant scar following scar revision surgery. | P2 |
Completed |
Burns Unspecified|Vision, Low |
2011-03-03 |
2022-03-12 |
Treatments |
|
| RN1001-0107 | P2 |
Completed |
Keloid |
2010-06-01 |
2019-03-18 |
Treatments |
|
| Juvista in the non-surgical improvement of existing scars | P2 |
Terminated |
Unknown |
2009-11-04 |
2022-03-12 |
Treatments |
|
| RN1001-0093 | P2 |
Completed |
Keloid |
2009-10-01 |
2019-03-18 |
Treatments |
|
| Juvista in varicose vein removal | P2 |
Completed |
Varicose Veins |
2009-04-02 |
2022-03-12 |
Treatments |
|
| RN1001-0064 | P2 |
Completed |
Keloid |
2009-03-01 |
2019-03-21 |
Treatments |
|
| RN1001-0042 | P2 |
Completed |
Varicose Veins |
2009-01-01 |
2019-03-21 |
Treatments |
|
| RN1001-319-1009 | P2 |
Unknown status |
Vision, Low |
2008-07-01 |
2019-03-21 |
||
| Juvista in breast reduction | P2 |
Terminated |
Injuries/wounds Unspecified |
2007-10-06 |
2022-03-12 |
Treatments |
|
| RN1001-319-1010 | P2 |
Completed |
Injuries/wounds Unspecified |
2007-10-01 |
2019-03-21 |
Treatments |
|
| RN1001-0036 | P2 |
Completed |
Healthy Volunteers|Injuries/wounds Unspecified |
2007-08-01 |
2019-03-18 |
Treatments |
|
| RN1001-319-1008 | P2 |
Unknown status |
Nevus |
2007-07-01 |
2019-03-18 |
Treatments |
|
| RN1001-0050 | P2 |
Completed |
Healthy Volunteers|Injuries/wounds Unspecified |
2007-03-01 |
2019-03-18 |
Treatments |
|
| RN1001-319-1007 | P2 |
Completed |
Injuries/wounds Unspecified |
2006-01-01 |
2019-03-19 |
||
| RN1001-319-1006 | P2 |
Completed |
Injuries/wounds Unspecified |
2004-08-01 |
2019-03-19 |
||
| RN1001-309-1002 | P2 |
Completed |
Injuries/wounds Unspecified|Healthy Volunteers |
2003-09-01 |
2019-03-18 |
Treatments |
|
| RN1001-319-1004 | P2 |
Completed |
Healthy Volunteers|Injuries/wounds Unspecified |
2003-09-01 |
2019-03-19 |
Treatments |
|
| RN1001-319-1005 | P2 |
Completed |
Injuries/wounds Unspecified |
2003-06-01 |
2019-03-18 |
Treatments |
|
| Juvista | P2 |
Completed |
Healthy Volunteers|Injuries/wounds Unspecified |
2002-11-01 |
2019-03-19 |
Treatments |
|
| Juvista in scar revision surgery of disfiguring scars | P3 |
Completed |
Vision, Low |
2011-01-30 |
2022-03-12 |
Treatments |
|
| Revise | P3 |
Completed |
Vision, Low|Depressive Disorder |
2011-01-01 |
2019-03-18 |
Treatments |