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REGN-5837

Alternative Names: REGN-5837, REGN 5837, REGN5837
Latest Update: 2024-12-09
Latest Update Note: News Article

Product Description

REGN5837, a bispecific antibody that clusters CD22-expressing tumor cells with CD28-expressing T cells, enhances odronextamab by potentiating T cell activation and cytolytic function. REGN5837 monotherapy shows limited activity and no toxicity in primate studies, it augments T cell activation when dosed in combination with odronextamab. (Sourced from: https://investor.regeneron.com/static-files/3f2c8835-1da3-43e6-a50d-7080d8d935ab)

Mechanisms of Action: CD22 Inhibitor,CD28 Inhibitor

Novel Mechanism: Yes

Modality: Bispecific Antibody

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Regeneron
Company Location: TARRYTOWN NY 10591
Company CEO: Leonard S. Schleifer
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for REGN-5837

Countries in Clinic: United States

Active Clinical Trial Count: 1

Highest Development Phases

Phase 1: Lymphoma, B-Cell|Lymphoma, Non-Hodgkin

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
ATHENA-1

P1

Recruiting

Lymphoma, B-Cell|Lymphoma, Non-Hodgkin

2027-06-02

Recent News Events

Date

Type

Title

12/09/2024

News Article

 Odronextamab ASH Presentations Underscore Impressive Potential in Earlier Lines of Treatment and Additional Types of Lymphoma

08/26/2024

News Article

 Ordspono™ (odronextamab) Approved in the European Union for the Treatment of Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma

06/28/2024

News Article

 Odronextamab Recommended for EU Approval by the CHMP to Treat Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma

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