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PYX-201

Alternative Names: PYX-201, PYX201, PYX 201
Latest Update: 2024-11-20
Latest Update Note: News Article

Product Description

PYX-201 is a first-in-class non-internalizing ADC that targets extra domain-B (EDB) of fibronectin for oncological indications. (Sourced from: https://pyxisoncology.com/2021/04/27/pyxis-oncology-presents-preclinical-data-and-details-on-antibody-drug-conjugate-candidates-supporting-therapeutic-potential/)

Mechanisms of Action: EDB-FN Binder

Novel Mechanism: Yes

Modality: Antibody Drug Conjugate

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Pyxis Oncology
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for PYX-201

Countries in Clinic: Belgium, Spain, United States

Active Clinical Trial Count: 1

Highest Development Phases

Phase 1: Oncology Solid Tumor Unspecified

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
PYX-201-101

P1

Recruiting

Oncology Solid Tumor Unspecified

2026-07-01

Recent News Events

Date

Type

Title

12/19/2024

News Article

 Pyxis Oncology Announces Portfolio Prioritization, Focusing Resources on its Lead Clinical Program, PYX-201

11/20/2024

News Article

 Pyxis Oncology Announces Favorable Preliminary PYX-201 Clinical Phase 1 Part 1 Data

08/29/2024

News Article

 Pyxis Oncology to Participate in Two Upcoming Investor Conferences

07/29/2024

News Article

 Pyxis Oncology to Participate in the BTIG Virtual Biotechnology Conference

08/01/2023

PubMed

 Development and validation of a hybrid immunoaffinity LC-MS/MS assay for quantitation of total antibody (TAb) from an antibody drug conjugate (ADC) PYX-201 in human plasma.

07/15/2023

PubMed

 A sensitive and rapid LC-MS/MS assay for quantitation of free payload Aur0101 from antibody drug conjugate (ADC) PYX-201 in human plasma.

07/01/2023

PubMed

 A sensitive LC-MS/MS assay to quantitate free payload Aur0101 from ADC PYX-201 in rat and monkey plasma.

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