AZD-5863

Product Description

HBM7022 is a bispecific antibody that crosslinks tumor cells and T cells by targeting a tumor-associated antigen (Claudin18.2) and CD3 and thus leads to potent T cell activation and tumor elimination. By using bivalent high affinity anti-Claudin18.2 and monovalent low affinity anti-CD3, HBM7022 has demonstrated potent cytotoxicity but low cytokine release syndrome risk. Preclinical studies have shown that it can treat not only wild type Claudin18.2 positive gastric cancer, but also pancreatic cancer and mutated Claudin18.2 gastric cancer. HBM7022 is one of the fully human bispecific antibodies developed from the HBICE® Platform of the Company. (Sourced from: https://www.prnewswire.com/news-releases/harbour-biomed-announces-global-out-license-agreement-with-astrazeneca-for-cldn18-2xcd3-bispecific-antibody-hbm7022--301519595.html#:~:text=HBM7022%20is%20a%20bispecific%20antibody,cell%20activation%20and%20tumor%20elimination.)

Mechanisms of Action: CLDN18.2 Inhibitor,CD3 Inhibitor

Novel Mechanism: No

Modality: Bispecific Antibody

Route of Administration: Intravenous,Subcutaneous

FDA Designation: *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: AstraZeneca
Company Location: CAMBRIDGE X0 CB2 0AA
Company CEO: Pascal Soriot
Additional Commercial Interests: Harbour BioMed