Product Description
AV-353 is the Company's potent, selective, high affinity inhibitory antibody specific to Notch 3. The Notch 3 signaling pathway is important in cell-to-cell communication involving gene regulation mechanisms that control multiple cell differentiation processes during the entire life cycle. Scientific literature has implicated the Notch 3 receptor pathway in multiple diseases, including cancer, cardiovascular diseases and neurodegenerative conditions. AV-353 is being studied by AVEO's collaborators at the Mayo Clinic in preclinical studies of triple negative breast cancer. (Sourced from: https://www.aveooncology.com/product-candidates/av-353/)
Mechanisms of Action: NOTCH3 Antagonist
Novel Mechanism: Yes
Modality: Antibody
Route of Administration: N/A
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Company: LG Chem
Company Location:
Company Founding Year: 1947
Additional Commercial Interests: None
Clinical Description
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Highest Development Phases
Phase 0: Oncology Solid Tumor Unspecified
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