Product Description
Alvespimycin is an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. (Sourced from: https://pubchem.ncbi.nlm.nih.gov/compound/Alvespimycin)
Mechanisms of Action: HSP Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Intravenous
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Bristol-Myers Squibb
Company Location: NEW YORK NY 10016
Company CEO: Giovanni Caforio
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 2: Breast Cancer
Phase 1: Oncology Solid Tumor Unspecified|Breast Cancer|Adenoid Cystic Carcinoma|Mucoepidermoid Carcinoma|Olfactory Esthesioneuroblastoma|Colorectal Cancer|Ovarian Cancer|Laryngeal Cancer|Renal Cell Carcinoma|Ovarian Diseases|Prolymphocytic B-Cell Leukemia|Lymphocytic Chronic B-Cell Leukemia|Chronic Lymphoid Leukemia|Intestinal Cancer|Lymphoma|Prolymphocytic Leukemia|Lymphoma, B-Cell|Breast Diseases|Salivary Gland Cancer|Dermoid Cyst|Prostate Cancer|Kidney Diseases|Gastrointestinal Cancer|Squamous Cell Carcinoma|Paranasal Sinus Cancer|Stomach Diseases|Nasopharyngeal Cancer|Basal Cell Carcinoma|Colonic Diseases|Mucoepidermoid Tumor|Prostatic Diseases|Nasopharyngeal Diseases|Male Breast Cancer|Oropharyngeal Cancer|Paranasal Sinus Diseases|Melanoma|Salivary Gland Diseases|Head and Neck Cancer|Papilloma, Inverted|Granuloma, Lethal Midline|Verrucous Carcinoma|Granuloma, Laryngeal
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| B-PLL | P1 |
Terminated |
Prolymphocytic B-Cell Leukemia|Lymphocytic Chronic B-Cell Leukemia|Chronic Lymphoid Leukemia|Prolymphocytic Leukemia|Lymphoma, B-Cell |
2012-06-01 |
|
| 04-C-0218 | P1 |
Completed |
Intestinal Cancer|Lymphoma |
2010-03-01 |
|
| CA201-001 | P1 |
Completed |
Breast Cancer |
2009-08-01 |
|
| CA201-002 | P2 |
Terminated |
Breast Cancer |
2008-06-01 |