Product Description
A-319 is a T-cell activating bispecific antibody (BsAb) designed to target CD19 and CD3 (anti-CD19, anti-CD3) and is under development for the treatment of patients with B cell malignancies including B-cell leukemia and B-cell lymphoma. A-319 activates T lymphocytes in a patient to kill CD19 expressing malignant B-cells. (Sourced from: https://www.businesswire.com/news/home/20181111005067/en/Generon-Receives-Investigative-New-Drug-IND-Approval-from-China-SFDA-for-A-319-to-Treat-Patients-with-B-Cell-Malignancies)
Mechanisms of Action: CD19 Inhibitor,CD3 Inhibitor
Novel Mechanism: No
Modality: Bispecific Antibody
Route of Administration: Intravenous
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Generon Pharmaceutical Technology (Shanghai) Co., Ltd.
Company Location:
Company CEO:
Additional Commercial Interests: None
Clinical Description
Countries in Clinic: China
Active Clinical Trial Count: 3
Recent & Upcoming Milestones
Highest Development Phases
Phase 1: Acute Lymphoid Leukemia|B-Cell Leukemia|Lupus Erythematosus, Systemic|Lymphoma, B-Cell
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|
| UHCT240243 | P1 |
Recruiting |
Lupus Erythematosus, Systemic |
2025-05-01 |
23% |
2025-04-16 |
Patient Enrollment|Primary Endpoints|Treatments |
| CTR20210368 | P1 |
Recruiting |
Acute Lymphoid Leukemia|B-Cell Leukemia |
None |
2025-04-29 |
Patient Enrollment|Treatments |
|
| CTR20190205 | P1 |
Recruiting |
Lymphoma, B-Cell |
None |
2025-04-29 |
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