Product Description
Alfimeprase, a fibrolase derivative with thrombolytic activity produced by recombinant DNA technology, was discovered by Amgen and was in development with Nuvelo for the treatment of stroke and catheter occlusion. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/18457471/)
Mechanisms of Action: Fibrin Hydrolyzer
Novel Mechanism: Yes
Modality: Coagulation Factor
Route of Administration: N/A
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: ARCA Biopharma
Company Location:
Company CEO: Michael R. Bristow
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 3: Arterial Occlusive Diseases|Venous Thrombosis|Acute Coronary Syndrome|Coronary Occlusion|Coronary Disease|Stroke|Peripheral Arterial Disease
Phase 2: Arterial Occlusive Diseases|Peripheral Arterial Disease|Thrombosis|Peripheral Vascular Diseases|Injuries/wounds Unspecified|Ischemic Stroke|Venous Thrombosis
Trial ID |
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|---|
NCT00499902 |
CARNEROS-1 | P2 |
Terminated |
Ischemic Stroke |
2008-05-01 |
2019-03-21 |
Treatments |
|
2007-005254-24 |
CARNEROS-1 | P2 |
Terminated |
Ischemic Stroke |
2008-03-17 |
2025-05-06 |
Treatments |
|
2006-000545-19 |
SONOMA-3 | P2 |
Completed |
Injuries/wounds Unspecified |
2007-08-03 |
2022-03-12 |
Treatments |
|
NCT00073554 |
HA002 | P2 |
Completed |
Arterial Occlusive Diseases|Peripheral Arterial Disease|Thrombosis|Peripheral Vascular Diseases |
None |
2019-03-21 |
Treatments |
|
NCT00073515 |
HA003 | P2 |
Completed |
Venous Thrombosis |
None |
2019-03-21 |
||
NCT00115999 |
HA004 | P3 |
Completed |
Arterial Occlusive Diseases |
2007-02-01 |
2019-03-21 |
Treatments |
|
2005-004901-27 |
2005-004901-27 | P3 |
Terminated |
Coronary Disease|Coronary Occlusion|Stroke|Acute Coronary Syndrome|Peripheral Arterial Disease |
2007-05-24 |
2022-03-12 |
Treatments |
|
NCT00338585 |
NAPA-3 | P3 |
Terminated |
Arterial Occlusive Diseases |
2007-03-01 |
2019-03-21 |
Treatments |
|
2005-003282-16 |
2005-003282-16 | P3 |
Completed |
Unknown |
2006-10-17 |
2022-03-12 |
Treatments |
|
NCT00346424 |
HA006 | P3 |
Completed |
Venous Thrombosis |
2006-10-01 |
2019-03-21 |
Treatments |
|
2004-002950-67 |
2004-002950-67 | P3 |
Completed |
Unknown |
2006-04-06 |
2022-03-12 |
Treatments |
|
NCT00322270 |
SONOMA-3 | P3 |
Completed |
Venous Thrombosis |
None |
2019-03-21 |
Treatments |
Recent News Events
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