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Vorsetuzumab mafodotin

Alternative Names: vorsetuzumab mafodotin, denintuzumab mafodotin, sgn-cd19a, sgn-75, abt-414
Latest Update: 2024-02-20
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: Tubulin Inhibitor,Mitosis Inhibitor

Novel Mechanism: No

Modality: Bispecific Antibody

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: AbbVie
Company Location: NORTH CHICAGO IL 60064
Company CEO: Richard A. Gonzalez
Additonal Commercial Interests: None

Clinical Description

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Glioblastoma|Gliosarcoma

Phase 2: Diffuse Large B-Cell Lymphoma|Glioblastoma|Glioma|Follicular Lymphoma

Phase 1: Renal Cell Carcinoma|Follicular Lymphoma|Lymphoma, Non-Hodgkin|Mantle-Cell Lymphoma|B-Cell Leukemia|Diffuse Large B-Cell Lymphoma|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Burkitt Lymphoma|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Lymphoma, B-Cell|Lymphoid Leukemia|Oncology Solid Tumor Unspecified|Glioblastoma

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
2015-001166-26

P3

Completed

Gliosarcoma|Glioblastoma

2022-04-04

Intellance1

P3

Completed

Gliosarcoma|Glioblastoma

2022-04-04

M13-714

P2

Completed

Glioma|Glioblastoma

2020-08-27

41%
2017-003171-64

P3

Completed

Glioblastoma

2020-03-03

Recent News Events

Date

Type

Title

02/20/2024

PubMed

 Efficacy of Depatuxizumab Mafodotin (ABT-414) in preclinical models of head and neck cancer.

07/12/2022

PubMed

 Biodistribution Analysis of an Anti-EGFR Antibody in the Rat Brain: Validation of CSF Microcirculation as a Viable Pathway to Circumvent the Blood-Brain Barrier for Drug Delivery.

02/28/2022

PubMed

 Antibody-Drug Conjugates Targeting the Human Epidermal Growth Factor Receptor Family in Cancers.

05/30/2019

News Article

 AbbVie Presents Results from Several Studies and Clinical Trials Investigating Medicines Across More than 15 Cancers at the 2019 ASCO and EHA Meetings

05/17/2019

News Article

 AbbVie Provides Update on Depatuxizumab Mafodotin (Depatux-M), an Investigational Medicine for Newly Diagnosed Glioblastoma, an Aggressive Form of Brain Cancer

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