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Begacestat

Alternative Names: begacestat, gsi-953
Latest Update: 2023-06-25
Latest Update Note: PubMed Publication

Product Description

a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease (Sourced from: https://pubmed.ncbi.nlm.nih.gov/19671883/)

Mechanisms of Action: G-Secretase Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Pfizer
Company Location: NEW YORK NY 10017
Company CEO: Albert Bourla
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Begacestat

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 1: Alzheimer Disease

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
3183A1-1106

P1

Completed

Alzheimer Disease

2009-11-01

3183A1-102

P1

Completed

Alzheimer Disease

2009-10-01

3183A1-101

P1

Completed

Alzheimer Disease

2009-07-01

43%
3183A1-103

P1

Completed

Alzheimer Disease

2007-10-01

Recent News Events

Date

Type

Title

06/25/2023

PubMed

 Mesenchymal Stem Cells and Begacestat Mitigate Amyloid-beta 25-35-Induced Cognitive Decline in Rat Dams and Hippocampal Deteriorations in Offspring.

05/25/2023

PubMed

 Bone Marrow-Derived Mesenchymal Stem Cells and γ-Secretase Inhibitor Treatments Suppress Amyloid-β25-35-Induced Cognitive Impairment in Rat Dams and Cortical Degeneration in Offspring.

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