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Telcagepant

Alternative Names: telcagepant, mk-0974, mk0974
Latest Update: 2024-01-01
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: CGRP Antagonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Merck
Company Location: KENILWORTH NJ 07033
Company CEO: Robert M. Davis
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Telcagepant

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Migraine Disorders|Ischemic Stroke|Peripheral Arterial Disease|Peripheral Vascular Diseases|Cerebrovascular Disorders|Ischemic Attack, Transient|Coronary Artery Disease

Phase 2: Migraine Disorders

Phase 1: Migraine Disorders|Angina, Stable|Myocardial Ischemia|Angina Pectoris|Coronary Artery Disease

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
MK-0974-067

P1

Completed

Migraine Disorders

2011-07-26

MK0974-065

P3

Completed

Migraine Disorders

2011-04-08

MK-0974-065

P3

Completed

Migraine Disorders

2011-04-08

MK-0974-034

P3

Completed

Peripheral Vascular Diseases|Cerebrovascular Disorders|Migraine Disorders|Peripheral Arterial Disease|Ischemic Attack, Transient|Ischemic Stroke

2009-09-02

Recent News Events

Date

Type

Title

01/01/2024

PubMed

 CGRP receptor antagonists (gepants).

07/28/2023

PubMed

 Blocking the CGRP Receptor: Differences across Human Vascular Beds.

10/01/2022

PubMed

 The CGRP Receptor Antagonist MK0974 Induces EVI1(high) AML Cell Apoptosis by Disrupting ERK Signaling.

06/16/2022

News Article

 DILIsym Software Publication Outlines Impact on the CGRP Field for Migraine

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