Drug Search Results
More Filters [+]

Tadalafil

Alternative Names: tadalafil, cialis, adcirca, alyq, tadliq, entadfi
Latest Update: 2024-02-14
Latest Update Note: News Article

Product Description

Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. Tadalafil (Adcirca) is used to improve the ability to exercise in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Tadalafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow more easily. (Sourced from: https://medlineplus.gov/druginfo/meds/a604008.html)

Mechanisms of Action: PDE5 Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Approved

Approved Countries: Algeria | Argentina | Australia | Austria | Bangladesh | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Cyprus | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Estonia | European Medicines Agency | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | India | Indonesia | Ireland | Israel | Italy | Japan | Jordan | Korea | Latvia | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Mexico | Morocco | Netherlands | New Zealand | Norway | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sri Lanka | Sweden | Switzerland | Taiwan | Thailand | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam

Approved Indications: Hypertension | Hypertension, Pulmonary | Prostatic Hyperplasia

Known Adverse Events: Headache | Back Pain | Pain Unspecified | Myalgia | Dyspepsia | Flushing

Company: Eli Lilly
Company Location: INDIANAPOLIS IN 46285
Company CEO: David A. Ricks
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Tadalafil

Countries in Clinic: Australia, Belarus, Belgium, Brazil, Bulgaria, Canada, China, Czech Republic, Georgia, Germany, Hungary, Italy, Japan, Korea, Malaysia, Mexico, Poland, Russia, South Africa, Spain, Taiwan, Turkey, Ukraine, United States, Unknown Location

Active Clinical Trial Count: 17

Highest Development Phases

Phase 3: Erectile Dysfunction|Familial Primary Pulmonary Hypertension|Hypertension, Pulmonary|Obstetric Labor, Premature|Premature Ejaculation|Prostatic Hyperplasia

Phase 2: Colorectal Cancer

Phase 1: Alzheimer Disease|Healthy Volunteers

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

PLATYPUS

P3

Recruiting

Hypertension, Pulmonary

2027-01-31

95%

PLATYPUS

P3

Recruiting

Hypertension, Pulmonary

2027-01-31

95%

PLATYPUS

P3

Recruiting

Hypertension, Pulmonary

2027-01-31

95%

PLATYPUS

P3

Active, not recruiting

Hypertension, Pulmonary

2027-01-07

EMS0220 - TORONTO

P3

Not yet recruiting

Premature Ejaculation|Obstetric Labor, Premature|Erectile Dysfunction

2026-05-01

51%

2014-004786-25

P3

Active, not recruiting

Hypertension, Pulmonary

2024-03-05

Recent News Events