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Berberine

Alternative Names: Berberine
Latest Update: 2024-11-15
Latest Update Note: Clinical Trial Update

Product Description

berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism.

Mechanisms of Action: AMPK Activator

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: Australia | China | Hong Kong | India | Korea | New Zealand | Russia | Taiwan | United Arab Emirates | Vietnam

Approved Indications: None

Known Adverse Events: None

Company: Carmel Biosciences
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Berberine

Countries in Clinic: Armenia, China, Sweden

Active Clinical Trial Count: 4

Highest Development Phases

Phase 3: Type 2 Diabetes

Phase 1: Healthy Volunteers

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
EP-1007

P1

Not yet recruiting

Healthy Volunteers

2025-11-01

28%
HTD1801.PCT109

P3

Recruiting

Type 2 Diabetes

2025-07-01

63%
HTD1801.PCT109

P3

Recruiting

Type 2 Diabetes

2025-07-01

63%
Symphony1

P3

Active, not recruiting

Type 2 Diabetes

2025-03-01

Symphony2

P3

Active, not recruiting

Type 2 Diabetes

2025-03-01

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Date

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PubMed

 Berberine: Potential preventive and therapeutic strategies for human colorectal cancer.

05/13/2024

PubMed

 Inhibitory effect of phellodendrine on C48/80-induced allergic reaction in vitro and in vivo.

05/11/2024

PubMed

 Berberine inhibits intracellular Ca(2+) signals in mouse pancreatic acinar cells through M(3) muscarinic receptors: Novel target, mechanism, and implication.

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