Product Description
Mechanisms of Action: CDK9 Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Ophthalmic
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Cyclacel
Company Location: BERKELEY HEIGHTS NJ 07922
Company CEO:
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 2: Glaucoma, Open-Angle|Hypertension|Cystic Fibrosis|Non-Small-Cell Lung Cancer|Pituitary ACTH Hypersecretion|ACTH-Secreting Pituitary Adenoma
Phase 1: Oncology Solid Tumor Unspecified|Triple Negative Breast Cancer
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|
| CYC682-07 | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2019-07-16 |
2021-12-23 |
Patient Enrollment|Primary Completion Date|Primary Endpoints|Study Completion Date|Treatments|Trial Status |
|
| 1R01CA152228-01A1 | P1 |
Withdrawn |
Triple Negative Breast Cancer |
2015-09-01 |
2024-11-27 |
Primary Endpoints|Treatments |
|
| Pro52406 | P2 |
Recruiting |
ACTH-Secreting Pituitary Adenoma|Pituitary ACTH Hypersecretion |
2025-08-01 |
2023-09-14 |
||
| Pro35720 | P2 |
Terminated |
ACTH-Secreting Pituitary Adenoma|Pituitary ACTH Hypersecretion |
2018-10-01 |
2021-10-30 |
Patient Enrollment|Primary Endpoints |
|
| ROSCO-CF | P2 |
Terminated |
Cystic Fibrosis |
2018-07-26 |
2025-06-29 |
Treatments |
|
| ROSCO-CF | P2 |
Terminated |
Cystic Fibrosis |
2018-07-26 |
37% |
2019-03-20 |
Treatments |
| C-08-28 | P2 |
Completed |
Hypertension|Glaucoma, Open-Angle |
2009-10-01 |
2019-03-18 |
Treatments |
|
| CYC202-06-14 (A1) | P2 |
Terminated |
Non-Small-Cell Lung Cancer |
2009-03-03 |
2021-12-23 |
Patient Enrollment|Primary Completion Date|Primary Endpoints|Start Date|Study Completion Date|Treatments |
|
| extension study | P2 |
Terminated |
Non-Small-Cell Lung Cancer |
2006-01-11 |
2022-03-12 |
Treatments |