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Bafetinib

Alternative Names: bafetinib, inno-406
Latest Update: 2023-11-20
Latest Update Note: PubMed Publication

Product Description

An orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). (Sourced from: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/bafetinib)

Mechanisms of Action: Bcr-Abl Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: CytRx
Company Location: LOS ANGELES CA 90049
Company CEO: Stephen Snowdy
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Bafetinib

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Lymphocytic Chronic B-Cell Leukemia|Chronic Lymphoid Leukemia|Prostate Cancer

Phase 1: Chronic Lymphoid Leukemia|Astrocytoma|Acute Lymphoid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Chronic Myeloid Leukemia|Acute Myeloid Leukemia|Giant Cell Tumors|Glioblastoma|Ependymoma|Gliosarcoma|Oligodendroglioma|Brain Cancer

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

BAFETINIB-P1-GBM-01

P1

Completed

Oligodendroglioma|Glioblastoma|Ependymoma|Gliosarcoma|Astrocytoma|Giant Cell Tumors|Brain Cancer

2013-03-01

BAFETINIB-P2-CLL-01

P2

Completed

Lymphocytic Chronic B-Cell Leukemia|Chronic Lymphoid Leukemia

2011-12-01

PROACT

P2

Completed

Prostate Cancer

2011-09-01

INNO-406

P1

Completed

Myelogenous, Chronic, BCR-ABL Positive Leukemia|Acute Lymphoid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myeloid Leukemia|Chronic Lymphoid Leukemia|Acute Myeloid Leukemia

2008-05-01

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