Ozmosi | Bafetinib Drug Profile

Product Description

An orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). (Sourced from: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/bafetinib)

Mechanisms of Action: Bcr-Abl Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: CytRx
Company Location: LOS ANGELES CA 90049
Company CEO: Stephen Snowdy
Additional Commercial Interests: None

Clinical Description

Countries in Clinic:

Active Clinical Trial Count:

Recent & Upcoming Milestones

Highest Development Phases

Phase 2: Lymphocytic Chronic B-Cell Leukemia|Chronic Lymphoid Leukemia|Prostate Cancer

Trial	Phase	Trial Status	Disease	Primary Completion Date	Latest Trial Update Date	Data Updated
BAFETINIB-P1-GBM-01	P1	Completed	Giant Cell Tumors\|Astrocytoma\|Gliosarcoma\|Glioblastoma\|Ependymoma\|Oligodendroglioma\|Brain Cancer	2013-03-01	2019-03-19	Treatments
BAFETINIB-P2-CLL-01	P2	Completed	Chronic Lymphoid Leukemia\|Lymphocytic Chronic B-Cell Leukemia	2011-12-01	2019-03-19	Treatments
PROACT	P2	Completed	Prostate Cancer	2011-09-01	2019-03-19	Treatments
INNO-406	P1	Completed	Acute Myeloid Leukemia\|Myelogenous, Chronic, BCR-ABL Positive Leukemia\|Chronic Lymphoid Leukemia\|Precursor Cell Lymphoblastic Leukemia-Lymphoma\|Chronic Myeloid Leukemia\|Acute Lymphoid Leukemia	2008-05-01	2019-03-21	Treatments

Recent News Events

Date	Type	Title
11/20/2023	PubMed	Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors.
11/16/2023	PubMed	Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions.
09/08/2023	PubMed	Tyrosine Kinase Inhibitor Profiling Using Multiple Forskolin-Responsive Reporter Cells.

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Bafetinib

Alternative Names: bafetinib, inno-406 Clinical Status: Inactive Latest Update: 2023-11-20 Latest Update Note: PubMed Publication