Product Description
St. Jude Children's Research Hospital is developing sarcolysin as an anticancer medicine. It is a type of chemotherapy that works by slowing or stopping growth of cancer cells. It may be used to help prepare patients for hematopoietic cell transplant. (Sourced from: https://together.stjude.org/en-us/diagnosis-treatment/medicines-list/melphalan.html)
Mechanisms of Action: Alkylating Agent
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Intravenous
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: India | Russia
Approved Indications: None
Known Adverse Events: None
Company: City of Hope Medical Center
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 3: Neuroblastoma|Ganglioneuroblastoma|Preleukemia|Acute Myeloid Leukemia|Acute Lymphoid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Myelodysplastic Syndrome
Phase 2: Melanoma|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Lymphoma, Non-Hodgkin|Preleukemia|Lymphoma|Multiple Myeloma|Neuroblastoma|Leukemia|Chronic Myeloid Leukemia|Myeloid, Accelerated Leukemia|Sarcoma, Myeloid|Juvenile Myelomonocytic Leukemia,|Paroxysmal Hemoglobinuria|Acute Myeloid Leukemia|Graft vs Host Disease|Acute Lymphoid Leukemia|Myelodysplastic Syndrome|Anemia, Refractory, with Excess of Blasts|Chronic Myelomonocytic Leukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Acute Monocytic Leukemia|Lymphocytic Chronic B-Cell Leukemia|Anemia, Aplastic|HIV Infections|Plasmablastic Lymphoma|Prolymphocytic Leukemia|Acute Myelomonocytic Leukemia|Lymphoma, B-Cell|Leukemia, Plasma Cell|Burkitt Lymphoma|Blast Crisis|Biphenotypic Acute Leukemia|Myeloproliferative Disorders|Hodgkin Lymphoma|T-Cell Lymphoma|Chronic Lymphoid Leukemia|Histiocytosis, Langerhans-Cell|Follicular Lymphoma|Waldenstrom Macroglobulinemia|Large-Cell Immunoblastic Lymphoma|Mantle-Cell Lymphoma|Myelodysplastic-Myeloproliferative Diseases|Crohn Disease|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|B-Cell Leukemia|Adult T-Cell Leukemia-Lymphoma|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Myelofibrosis|Polycythemia Vera|Prolymphocytic T-Cell Leukemia|Prolymphocytic B-Cell Leukemia|Thrombocytosis|Thrombocythemia, Essential
Phase 1: Acute Lymphoid Leukemia|Lymphoma, B-Cell|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Lymphoma|Neuroblastoma|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Biphenotypic Acute Leukemia|Preleukemia|Chronic Lymphoid Leukemia|Multiple Myeloma|Leukemia, Plasma Cell|Myelodysplastic Syndrome|Myeloid, Accelerated Leukemia|Chronic Myeloid Leukemia|Myeloproliferative Disorders|Lymphocytic Chronic B-Cell Leukemia|Acute Myeloid Leukemia|Sarcoma, Ewing|Lymphoma, Non-Hodgkin|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Acute Myelomonocytic Leukemia|Juvenile Myelomonocytic Leukemia,|Clear Cell Sarcoma|Anemia, Aplastic|Rhabdoid Tumor|Blast Crisis|Acute Monocytic Leukemia|Chronic Myelomonocytic Leukemia|Gastrointestinal Cancer|Clear Cell Adenocarcinoma|Wilms Tumor|Renal Cell Carcinoma|Rhabdomyosarcoma|Adenomyoepithelioma|Melanoma
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| NCI-2023-08530 | P3 |
Recruiting |
Ganglioneuroblastoma |
2029-12-31 |
|
| ASCT2031 | P3 |
Recruiting |
Acute Myeloid Leukemia|Preleukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Acute Lymphoid Leukemia|Myelodysplastic Syndrome |
2027-12-01 |
|
| PRO11090340 | P2 |
Recruiting |
Crohn Disease |
2025-12-01 |
|
| NCI-2016-00584 | P2 |
Recruiting |
Preleukemia|Lymphoma, B-Cell|Leukemia, Plasma Cell|Anemia, Refractory, with Excess of Blasts|Lymphoma, Non-Hodgkin|Multiple Myeloma|B-Cell Leukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Juvenile Myelomonocytic Leukemia,|Chronic Myelomonocytic Leukemia|Acute Myeloid Leukemia|Myeloid, Accelerated Leukemia|Biphenotypic Acute Leukemia|Myelodysplastic Syndrome|Chronic Lymphoid Leukemia|Acute Myelomonocytic Leukemia|Myeloproliferative Disorders|Acute Monocytic Leukemia|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myeloid Leukemia|Myelodysplastic-Myeloproliferative Diseases|Acute Lymphoid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma |
2025-05-31 |