Product Description
St. Jude Children's Research Hospital is developing sarcolysin as an anticancer medicine. It is a type of chemotherapy that works by slowing or stopping growth of cancer cells. It may be used to help prepare patients for hematopoietic cell transplant. (Sourced from: https://together.stjude.org/en-us/diagnosis-treatment/medicines-list/melphalan.html)
Mechanisms of Action: Alkylating Agent
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Intravenous
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: India | Russia
Approved Indications: None
Known Adverse Events: None
Company: City of Hope Medical Center
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description

Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 3: Ganglioneuroblastoma|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Acute Lymphoid Leukemia|Myelodysplastic Syndrome|Acute Myeloid Leukemia|Neuroblastoma|Preleukemia
Phase 2: Graft vs Host Disease|Lymphoma|Crohn Disease|Leukemia|Multiple Myeloma|Preleukemia|Melanoma|Myelodysplastic Syndrome|Blast Crisis|Myeloid, Accelerated Leukemia|Acute Myeloid Leukemia|Acute Myelomonocytic Leukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Chronic Myeloid Leukemia|Anemia, Refractory, with Excess of Blasts|Leukemia, Plasma Cell|Hodgkin Lymphoma|Acute Monocytic Leukemia|Neuroblastoma|Chronic Myelomonocytic Leukemia|Juvenile Myelomonocytic Leukemia,|Paroxysmal Hemoglobinuria|Myeloproliferative Disorders|Acute Lymphoid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|B-Cell Leukemia|Sarcoma, Myeloid|Lymphoma, Non-Hodgkin|Lymphoma, B-Cell|Prolymphocytic Leukemia|Chronic Lymphoid Leukemia|Anemia, Aplastic|Myelodysplastic-Myeloproliferative Diseases|Lymphocytic Chronic B-Cell Leukemia|HIV Infections|Mantle-Cell Lymphoma|Large-Cell Immunoblastic Lymphoma|Burkitt Lymphoma|Prolymphocytic B-Cell Leukemia|Thrombocythemia, Essential|Thrombocytosis|T-Cell Lymphoma|Adult T-Cell Leukemia-Lymphoma|Biphenotypic Acute Leukemia|Follicular Lymphoma|Prolymphocytic T-Cell Leukemia|Plasmablastic Lymphoma|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Waldenstrom Macroglobulinemia|Histiocytosis, Langerhans-Cell|Myelofibrosis|Polycythemia Vera
Phase 1: Wilms Tumor|Rhabdomyosarcoma|Blast Crisis|Lymphoma, Non-Hodgkin|Adenomyoepithelioma|Rhabdoid Tumor|Melanoma|Acute Myeloid Leukemia|Renal Cell Carcinoma|Clear Cell Sarcoma|Lymphoma|Neuroblastoma|Gastrointestinal Cancer|Leukemia, Plasma Cell|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Lymphoma, B-Cell|Clear Cell Adenocarcinoma|Chronic Myeloid Leukemia|Myeloproliferative Disorders|Sarcoma, Ewing|Myelodysplastic Syndrome|Juvenile Myelomonocytic Leukemia,|Acute Myelomonocytic Leukemia|Acute Lymphoid Leukemia|Anemia, Aplastic|Preleukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Chronic Lymphoid Leukemia|Multiple Myeloma|Chronic Myelomonocytic Leukemia|Myeloid, Accelerated Leukemia|Lymphocytic Chronic B-Cell Leukemia|Acute Monocytic Leukemia|Biphenotypic Acute Leukemia|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
---|---|---|---|---|---|
NCI-2023-08530 | P3 |
Recruiting |
Ganglioneuroblastoma |
2029-12-31 |
|
ASCT2031 | P3 |
Recruiting |
Myelodysplastic Syndrome|Acute Myeloid Leukemia|Preleukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Acute Lymphoid Leukemia |
2027-12-01 |
|
PRO11090340 | P2 |
Recruiting |
Crohn Disease |
2025-12-01 |
|
NCI-2016-00584 | P2 |
Recruiting |
Lymphoma, Non-Hodgkin|Myelodysplastic Syndrome|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Myeloproliferative Disorders|B-Cell Leukemia|Leukemia, Plasma Cell|Chronic Lymphoid Leukemia|Anemia, Refractory, with Excess of Blasts|Acute Monocytic Leukemia|Acute Lymphoid Leukemia|Acute Myeloid Leukemia|Biphenotypic Acute Leukemia|Myeloid, Accelerated Leukemia|Acute Myelomonocytic Leukemia|Juvenile Myelomonocytic Leukemia,|Lymphoma, B-Cell|Chronic Myeloid Leukemia|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Preleukemia|Multiple Myeloma|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myelomonocytic Leukemia|Myelodysplastic-Myeloproliferative Diseases |
2025-05-31 |