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Avosentan

Alternative Names: avosentan, spp-301, spp301, spp 301
Latest Update: 2023-02-08
Latest Update Note: PubMed Publication

Product Description

a predominant ETAreceptor antagonist (Sourced from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831858/)

Mechanisms of Action: ETa Antagonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Speedel Pharma
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Avosentan

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Diabetic Nephropathy|Kidney Failure, Chronic

Phase 2: Kidney Diseases

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
2008-000786-32

P2

Completed

Kidney Diseases

2009-09-11

ASCEND

P3

Terminated

Diabetic Nephropathy

2006-12-18

SPP301CRD15

P3

Terminated

Diabetic Nephropathy|Kidney Failure, Chronic

None

Recent News Events

Date

Type

Title

02/08/2023

PubMed

 Endothelin Receptor Antagonists in Kidney Disease.

11/07/2021

PubMed

 Endothelin Receptor Antagonists as a Potential Treatment of Diabetic Nephropathy: A Systematic Review.

01/01/2021

PubMed

 Efficacy and safety of endothelin receptor antagonists in type 2 diabetic kidney disease: A systematic review and meta-analysis of randomized controlled trials.

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