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GSK-1795091

Alternative Names: gsk-1795091, gsk1795091, gsk 1795091
Latest Update: 2022-11-01
Latest Update Note: PubMed Publication

Product Description

 a synthetic TLR4 agonist (Sourced from: https://pubmed.ncbi.nlm.nih.gov/32739049/)

Mechanisms of Action: TLR4 Agonist

Novel Mechanism: Yes

Modality: Large Molecule

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: GlaxoSmithKline
Company Location: BRENTFORD MIDDLESEX X0 TW8 9GS
Company CEO: Emma Walmsley
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for GSK-1795091

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 1: Healthy Volunteers|Oncology Unspecified|Oncology Solid Tumor Unspecified

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
NCT03447314

P1

Completed

Oncology Solid Tumor Unspecified

2020-07-01

NCT02798978

P1

Completed

Oncology Unspecified|Healthy Volunteers

2017-10-13

Recent News Events

Date

Type

Title

11/01/2022

PubMed

 Manufacturing-dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development.

08/01/2020

PubMed

 Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study.

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