Product Description
Prednisone is a synthetic, anti-inflammatory glucocorticoid that derives from cortisone. It is biologically inert and converted to prednisolone in the liver. Prednisone is an FDA-approved, delayed-release corticosteroid indicated as an anti-inflammatory or immunosuppressive agent to treat a broad range of diseases, including immunosuppressive/endocrine, rheumatic, collagen, dermatologic, allergic states, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, acute exacerbations of multiple sclerosis, and as an anti-inflammatory and an antineoplastic agent. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/30521230/)
Mechanisms of Action: GR Agonist,Immunosuppressive
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Approved
Approved Countries: Algeria | Argentina | Australia | Austria | Bangladesh | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Cyprus | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Finland | France | Germany | Hong Kong | Hungary | India | Indonesia | Ireland | Israel | Italy | Jordan | Korea | Lebanon | Lithuania | Malta | Mexico | Morocco | Netherlands | New Zealand | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sweden | Switzerland | Taiwan | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam
Approved Indications: Intestinal Diseases | Renal Transplant | Transplantation Unspecified | Kidney Diseases
Known Adverse Events: Weight Gain
Company: Johnson & Johnson
Company Location: NEW BRUNSWICK NJ 08933
Company CEO: Joaquin Duato
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Argentina, Australia, Belarus, Belgium, Brazil, Bulgaria, Canada, China, Czech Republic, Denmark, France, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Malaysia, Mexico, Netherlands, New Zealand, Poland, Portugal, Puerto Rico, Romania, Russia, Singapore, South Africa, Spain, Sweden, Taiwan, Thailand, Turkey, Ukraine, United Kingdom, United States
Active Clinical Trial Count: 38
Highest Development Phases
Phase 3: Bronchiolitis Obliterans|Drug Hypersensitivity|Graft vs Host Disease|Lymphoma, Non-Hodgkin|Multiple Myeloma|Prostate Cancer|Purpura, Thrombocytopenic, Idiopathic|T-Cell Peripheral Lymphoma|Thrombocytopenia
Phase 2: Depressive Disorder, Major|Diffuse Large B-Cell Lymphoma|Hodgkin Lymphoma|Lung Cancer|Pneumonia|Radiation Pneumonitis
Phase 1: Acute Lymphoid Leukemia|Acute Myeloid Leukemia|B-Cell Leukemia|Blast Crisis|Chronic Lymphoid Leukemia|Chronic Myeloid Leukemia|Lymphoma, B-Cell|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Precursor Cell Lymphoblastic Leukemia-Lymphoma
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| 2024-516905-22-00 | P3 |
Unknown Status |
Multiple Myeloma |
2031-12-31 |
|
| CRESCENDO | P3 |
Recruiting |
T-Cell Peripheral Lymphoma |
2030-07-01 |
|
| SHR6390-305 | P1 |
Not yet recruiting |
Prostate Cancer |
2028-12-01 |
39% |
| SHR6390-305 | P1 |
Not yet recruiting |
Prostate Cancer |
2028-12-01 |
39% |
| SHR6390-305 | P1 |
Not yet recruiting |
Prostate Cancer |
2028-12-01 |
39% |
| STUDY00016728 | P2 |
Active, not recruiting |
Prostate Cancer |
2028-01-01 |