Product Description
The anti-von Willebrand factor aptamer ARC1779 increases von Willebrand factor levels and platelet counts in patients with type 2B von Willebrand disease (Sourced from: https://pubmed.ncbi.nlm.nih.gov/22740102/)
Mechanisms of Action: VWF-A1 Inhibitor
Novel Mechanism: Yes
Modality: Nucleic Acid
Route of Administration: Intravenous
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Company: Archemix
Company Location:
Company Founding Year: None
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 2: Thromboembolism|Carotid Stenosis|Intracranial Embolism|Purpura, Thrombocytopenic|von Willebrand Diseases|Purpura, Thrombotic Thrombocytopenic|Thrombotic Microangiopathies|von Willebrand Disease, Type 2|Myocardial Infarction|Embolism
Phase 1: Thrombosis
Trial ID |
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|---|
NCT00432770 |
NCT00432770 | P1 |
Completed |
Thrombosis |
None |
2019-03-21 |
||
NCT00726544 |
ARC1779-006 | P2 |
Terminated |
Purpura, Thrombotic Thrombocytopenic|Thrombotic Microangiopathies|Purpura, Thrombocytopenic |
2010-12-01 |
2019-03-18 |
Treatments |
|
2008-005246-23 |
2008-005246-23 | P2 |
Terminated |
Embolism |
2010-01-27 |
2022-03-12 |
||
NCT00742612 |
ARC1779-008 | P2 |
Terminated |
Carotid Stenosis|Thromboembolism|Intracranial Embolism |
2010-01-01 |
2019-03-18 |
Treatments |
|
2008-001872-54 |
Study of ARC1779 Injection in Patients with Thrombotic Microangiopathy | P2 |
Terminated |
Unknown |
2009-11-13 |
2022-03-12 |
Treatments |
|
2008-008532-82 |
ARC1779 for VWD-2B | P2 |
Completed |
von Willebrand Diseases|von Willebrand Disease, Type 2 |
2009-08-07 |
2022-03-13 |
Treatments |
|
NCT00694785 |
ARC1779-010 | P2 |
Withdrawn |
von Willebrand Diseases|von Willebrand Disease, Type 2 |
2009-06-01 |
2019-03-18 |
Treatments |
|
2007-004371-19 |
2007-004371-19 | P2 |
Completed |
Purpura, Thrombotic Thrombocytopenic|Purpura, Thrombocytopenic|von Willebrand Diseases |
2008-12-09 |
2022-03-12 |
Treatments |
|
NCT00632242 |
ARC1779-004 | P2 |
Completed |
von Willebrand Disease, Type 2|Purpura, Thrombotic Thrombocytopenic|von Willebrand Diseases|Purpura, Thrombocytopenic |
2008-12-01 |
2019-03-18 |
Treatments |
|
2007-002547-25 |
vITAL-1 | P2 |
Terminated |
Myocardial Infarction |
2008-03-18 |
2025-06-13 |
Treatments |
Recent News Events
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