Drug Search Results

Perifosine

Alternative Names: perifosine
Latest Update: 2024-03-01
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: Akt Inhibitor,PI3K Modulator

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: AEterna Zentaris
Company Location: MONTREAL A8 H3B 3V2
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Perifosine

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Multiple Myeloma|Colorectal Cancer

Phase 2: Adenocarcinoma|Ovarian Cancer|Renal Cell Carcinoma|Prostate Cancer|Leukemia|Colorectal Cancer|Lymphoma|Chondrosarcoma|Cervical Cancer|Alveolar Soft Part Sarcoma|Waldenstrom Macroglobulinemia|Sarcoma|Endometrial Cancer|Gliosarcoma|Astrocytoma|Oligodendroglioma|Glioblastoma|Non-Small-Cell Lung Cancer|Multiple Myeloma|Gastrointestinal Stromal Tumors|Lymphoma, B-Cell|Lymphocytic Chronic B-Cell Leukemia|Pancreatic Cancer|Breast Cancer|Chronic Lymphoid Leukemia|Melanoma|Brain Cancer|Glioma|Head and Neck Cancer|Kidney Cancer

Phase 1: Diarrhea|Prostate Cancer|Chronic Lymphoid Leukemia|Myelodysplastic Syndrome|Acute Erythroblastic Leukemia|Multiple Myeloma|Renal Cell Carcinoma|Torsades de Pointes|HIV Infections|Pregnancy Outcomes|Myocardial Infarction|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Acute Myeloid Leukemia|Myeloproliferative Disorders|Colorectal Cancer|Heart Failure, Acute|Heart Failure, Chronic|Angina, Stable|Liver Cancer|Blast Crisis|Neuromyelitis Optica|Chronic Myelomonocytic Leukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Acute Promyelocytic Leukemia|Acute Monocytic Leukemia|Adult T-Cell Leukemia-Lymphoma|Acute Myelomonocytic Leukemia|Myeloid, Accelerated Leukemia|Acute Lymphoid Leukemia|Acute Megakaryoblastic Leukemia|Preleukemia|Kidney Cancer|Surgical Wound Infection|Contraception|Angina Pectoris|Angina, Unstable|Hypertrophy, Left Ventricular|Myelodysplastic-Myeloproliferative Diseases|Hypokalemia|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myeloid Leukemia|Hepatitis B, Chronic|Hepatitis C, Chronic|Oncology Solid Tumor Unspecified|Neuroblastoma|Astrocytoma|Ovarian Cancer|Glioblastoma|Brain Cancer|Oligodendroglioma|Lymphoma

Trial	Phase	Trial Status	Disease	Primary Completion Date	Probability of Success
NCT00590954	P2	Completed	Glioma\|Brain Cancer	2019-11-11
NCI-2011-01409	P2	Completed	Oligodendroglioma\|Glioblastoma\|Astrocytoma\|Gliosarcoma	2018-11-16
AAAM3801	P1	Completed	Glioblastoma\|Oligodendroglioma\|Astrocytoma\|Brain Cancer	2017-10-27
NCT00776867	P1	Completed	Oncology Solid Tumor Unspecified	2017-07-01

Recent News Events

Date	Type	Title
03/01/2024	PubMed	Neuroprotective effects of Rehmannia glutinosa polysaccharide on chronic constant light (CCL)-induced oxidative stress and autophagic cell death via the AKT/mTOR pathway in mouse hippocampus and HT-22 cells.
02/01/2024	PubMed	Study on the mechanism of CXCL12/CXCR4-axis-mediated upregulation of IL-8 and IL-6 on the biological function of acute T lymphocyte leukaemia cells.
01/15/2024	PubMed	ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials.

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