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Asunaprevir

Alternative Names: asunaprevir, bms-650032, sunvepra
Latest Update: 2024-03-01
Latest Update Note: PubMed Publication

Product Description

Asunaprevir is an orally bioavailable inhibitor of the nonstructural protein 3 (NS3), with potential activity against hepatitis C virus (HCV).  (Sourced from: https://pubchem.ncbi.nlm.nih.gov/compound/Asunaprevir)

Mechanisms of Action: HCV-NS3/4A Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: Canada | Chile | Colombia | Japan | Korea | New Zealand | Peru | Russia | Taiwan | Turkey

Approved Indications: None

Known Adverse Events: None

Company: Bristol-Myers Squibb
Company Location: NEW YORK NY 10016
Company CEO: Giovanni Caforio
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Asunaprevir

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 4: Hepatitis C, Chronic|Hepatitis A|Kidney Failure, Chronic

Phase 3: Hepatitis C|Hepatitis C, Chronic|Hepatitis A

Phase 2: Hepatitis C|Hepatitis A|Coinfection|Hepatitis C, Chronic|Liver Transplant|HIV Infections|Communicable Diseases

Phase 1: Hepatitis C|Hepatic Insufficiency|Liver Failure

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
C-DIAMOND

N/A

Unknown status

Hepatitis C, Chronic|Hepatitis A

2021-07-31

RELIF-C

N/A

Unknown status

Hepatitis A|Hepatitis C, Chronic|Liver Cirrhosis

2018-12-01

DARING

P3

Completed

Hepatitis C

2018-04-01

AI447-118

P4

Completed

Kidney Failure, Chronic|Hepatitis C, Chronic

2018-04-01

Recent News Events

Date

Type

Title

03/01/2024

PubMed

 The Role of CYPs and Transporters in the Biotransformation and Transport of the Anti-hepatitis C Antiviral Agents Asunaprevir, Daclatasvir, and Beclabuvir: Impact of Liver Disease, Race and Drug-drug Interactions on Safety and Efficacy.

02/22/2024

News Article

 Atomic AI Announces Appointments of New Independent Member to its Board of Directors and Additions to the Scientific Advisory Board

02/14/2024

PubMed

 Impacts of humic substances, elevated temperature, and UVB radiation on bacterial communities of the marine sponge Chondrilla sp.

01/24/2024

PubMed

 HCV antiviral drugs have the potential to adversely perturb the maternal-fetal communication axis through inhibition of CYP3A7 DHEA-S oxidation.

02/28/2023

News Article

 Revance Adds Experienced Pharmaceutical Executive to Board of Directors with Appointment of Dr. Vlad Coric, M.D., as Independent Director

04/11/2022

News Article

 Lucy Therapeutics Receives $4.9 Million Grant from Michael J. Fox Foundation

06/07/2019

News Article

 Japan Pharma, Healthcare, Regulatory and Reimbursement Landscape 2019-2020 - ResearchAndMarkets.com

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