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Orantinib

Alternative Names: orantinib, tsu-68
Latest Update: 2023-06-08
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: FGFR Antagonist,PGFR Inhibitor,VEGFR Inhibitor,TK Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Taiko Co
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Orantinib

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Hepatocellular Carcinoma

Phase 2: Hepatocellular Carcinoma|Gastrointestinal Cancer|Breast Cancer|Colorectal Cancer

Phase 1: Pancreatic Cancer|Hepatocellular Carcinoma|Prostate Cancer|Breast Cancer|Multiple Myeloma|Colorectal Cancer|Gastrointestinal Cancer|Lung Cancer|Kidney Cancer|Plasmacytoma|Non-Small-Cell Lung Cancer

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
JapicCTI-101354

P3

Terminated

Hepatocellular Carcinoma

2016-05-31

ORIENTAL

P3

Terminated

Hepatocellular Carcinoma

2014-06-01

JapicCTI-121970

P1

Completed

Hepatocellular Carcinoma

2013-03-31

JapicCTI-111403

P2

Completed

Colorectal Cancer

2012-12-31

Recent News Events

Date

Type

Title

06/08/2023

PubMed

 Transarterial chemoembolization with or without multikinase inhibitors for patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis of randomized controlled trials.

05/01/2023

PubMed

 Structure-based virtual screening of chemical libraries as potential MELK inhibitors and their therapeutic evaluation against breast cancer.

03/06/2023

PubMed

 A new molecular subclassification and in silico predictions for diagnosis and prognosis of papillary thyroid cancer by alternative splicing profile.

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