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ABBV-176

Alternative Names: abbv-176, abbv176, abbv 176
Latest Update: 2023-01-13
Latest Update Note: PubMed Publication

Product Description

ABBV-176 is an antibody-drug conjugate composed of the humanized antibody h16f (PR-1594804) conjugated to a highly potent, cytotoxic cross-linking pyrrolobenzodiazepine dimer (PBD; SGD-1882) targeting the prolactin receptor (PRLR), which is overexpressed in several solid tumor types. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/32524319/)

Mechanisms of Action: Prolactin Receptor Modulator

Novel Mechanism: Yes

Modality: Antibody Drug Conjugate

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: AbbVie
Company Location: NORTH CHICAGO IL 60064
Company CEO: Richard A. Gonzalez
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for ABBV-176

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 1: Colorectal Cancer|Breast Cancer|Adrenocortical Carcinoma|Hepatocellular Carcinoma|Renal Cell Carcinoma

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
PRLR

P1

Terminated

Colorectal Cancer|Hepatocellular Carcinoma|Adrenocortical Carcinoma|Breast Cancer|Renal Cell Carcinoma

2018-11-27

50%

Recent News Events

Date

Type

Title

01/13/2023

PubMed

 Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies.

06/09/2021

PubMed

 ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition.

12/01/2020

PubMed

 A first-in-human, phase 1, dose-escalation study of ABBV-176, an antibody-drug conjugate targeting the prolactin receptor, in patients with advanced solid tumors.

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