Vidutolimod

Product Description

Vidutolimod is an immune activator that stimulates T cells to attack tumors. It is a non-infectious, biologic virus-like particle (VLP) containing CpG-A DNA. Vidutolimod works by two complementary mechanisms that together have a unique ability to drive a strong systemic anti-tumor T cell response. First, the VLP activates an immune response to the VLP, leading to the production of antibodies that deliver the VLP into plasmacytoid dendritic cells (pDC) and other immune cells via specialized receptors called FcR . This provides an initial stimulatory signal to pDC and brings the CpG-A to TLR9 (the receptor for CpG DNA) inside the (pDC). Second, CpG-A stimulates TLR9 in a manner that induces significantly higher levels of type I interferons (IFN-alpha and others) in pDC resulting in a stronger anti-tumor T cell response, as compared to other innate immune activators. (Sourced from: https://checkmatepharma.com/our-science/vidutolimod-platform-technology/

Mechanisms of Action: Vaccine, TLR9

Novel Mechanism: Yes

Modality: Vaccine

Route of Administration: Subcutaneous

FDA Designation: Fast Track - Melanoma *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Regeneron
Company Location: Eastern America
Company Founding Year: 1988
Additional Commercial Interests: Kuros