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Vidutolimod

Alternative Names: vidutolimod, cmp-001, cmp001, cmp 001, cyt-003, cyt003, cyt 003, cyt003-qbg10, cyt003qbg10, cyt003 qbg10
Latest Update: 2024-08-28
Latest Update Note: Clinical Trial Update

Product Description

Vidutolimod is an immune activator that stimulates T cells to attack tumors. It is a non-infectious, biologic virus-like particle (VLP) containing CpG-A DNA. Vidutolimod works by two complementary mechanisms that together have a unique ability to drive a strong systemic anti-tumor T cell response. First, the VLP activates an immune response to the VLP, leading to the production of antibodies that deliver the VLP into plasmacytoid dendritic cells (pDC) and other immune cells via specialized receptors called FcR . This provides an initial stimulatory signal to pDC and brings the CpG-A to TLR9 (the receptor for CpG DNA) inside the (pDC). Second, CpG-A stimulates TLR9 in a manner that induces significantly higher levels of type I interferons (IFN-alpha and others) in pDC resulting in a stronger anti-tumor T cell response, as compared to other innate immune activators. (Sourced from: https://checkmatepharma.com/our-science/vidutolimod-platform-technology/

Mechanisms of Action: Vaccine,TLR9

Novel Mechanism: Yes

Modality: Vaccine

Route of Administration: Subcutaneous

FDA Designation: Fast Track - Melanoma *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Regeneron
Company Location: TARRYTOWN NY 10591
Company CEO: Leonard S. Schleifer
Additonal Commercial Interests: Kuros

Clinical Description

Map of Global Clinical Trials for Vidutolimod

Countries in Clinic: Australia, France, United States

Active Clinical Trial Count: 8

Highest Development Phases

Phase 3: Melanoma

Phase 2: Basal Cell Carcinoma|Carcinoma, Merkel Cell|Head and Neck Cancer|Lymphoma|Non-Small-Cell Lung Cancer|Squamous Cell Carcinoma|Triple Negative Breast Cancer

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

HCC 20-049

P2

Active, not recruiting

Melanoma

2028-07-30

NCT03983668

P2

Suspended

Lymphoma

2025-04-01

CMP-001-009

P2

Active, not recruiting

Carcinoma, Merkel Cell|Basal Cell Carcinoma|Triple Negative Breast Cancer|Non-Small-Cell Lung Cancer|Squamous Cell Carcinoma

2024-10-31

CMP-001-011

P3

Completed

Melanoma

2024-07-22

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