Product Description
AE 941 [Arthrovas, Neoretna, Psovascar] is shark cartilage extract that inhibits angiogenesis. AE 941 acts by blocking the two main pathways that contribute to the process of angiogenesis, matrix metalloproteases and the vascular endothelial growth factor signalling pathway. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/15293867/)
Mechanisms of Action: Angiogenesis Inhibitor
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: AEterna Zentaris
Company Location: MONTREAL A8 H3B 3V2
Company CEO:
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 3: Adenocarcinoma|Squamous Cell Carcinoma|Large Cell Carcinoma|Carcinoma, Adenosquamous|Renal Cell Carcinoma|Non-Small-Cell Lung Cancer|Kidney Cancer
Phase 2: Multiple Myeloma|Plasmacytoma
Trial ID |
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|---|
NCT00022282 |
CDR0000068801 | P2 |
Completed |
Multiple Myeloma|Plasmacytoma |
2007-03-01 |
2019-03-21 |
Treatments |
|
NCT00005995 |
CDR0000067999 | P3 |
Completed |
Kidney Cancer|Renal Cell Carcinoma |
2007-03-01 |
2019-03-21 |
||
NCT00005838 |
NCI-2012-02725 | P3 |
Completed |
Carcinoma, Adenosquamous|Non-Small-Cell Lung Cancer|Squamous Cell Carcinoma|Adenocarcinoma|Large Cell Carcinoma |
2007-02-01 |
2020-10-26 |
Primary Endpoints |