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SGT-53

Alternative Names: sgt-53, sgt53, sgt 53
Latest Update: 2023-12-03
Latest Update Note: PubMed Publication

Product Description

SGT-53 is a complex composed of a wild type p53 gene (plasmid DNA) encapsulated in a liposome that is targeted to tumor cells by means of an anti-transferrin receptor single-chain antibody fragment (TfRscFv) attached to the outside of the liposome. Pre-clinical studies have indicated that SGT-53 could sensitize tumors to the effects of radiation/chemotherapy. (Sourced from: https://clinicaltrials.gov/ct2/show/NCT00470613)

Mechanisms of Action: Gene Therapy

Novel Mechanism: No

Modality: Gene Therapy

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Amgen
Company Location: THOUSAND OAKS CA 91320
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for SGT-53

Countries in Clinic: United States

Active Clinical Trial Count: 1

Highest Development Phases

Phase 1: Oncology Unspecified

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
SGT53-00-1

P1

Not yet recruiting

Oncology Unspecified

2023-12-01

27%

Recent News Events

Date

Type

Title

12/03/2023

PubMed

 A Second Career for p53 as A Broad-Spectrum Antiviral?

03/24/2023

PubMed

 Nanoparticles overcome adaptive immune resistance and enhance immunotherapy via targeting tumor microenvironment in lung cancer.

10/31/2022

PubMed

 A Novel P53 Nanomedicine Reduces Immunosuppression and Augments Anti-PD-1 Therapy for Non-Small Cell Lung Cancer in Syngeneic Mouse Models.

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