Contact Us
Drug Search Results
More Filters [+]

GW-590735

Alternative Names: gw-590735, gw590735, gw 590735
Latest Update: 2022-07-01
Latest Update Note: PubMed Publication

Product Description

GW 590735 is a selective and potent agonist of peroxisome proliferator-activated receptor alpha (PPAR_), a ligand-activated transcription factor that plays a key role in lipid homeostasis. Activation of PPAR_ results in increased clearance of triglyceride (TG) rich very low-density lipoprotein. GW 590735 was in phase II clinical trial for the treatment of dyslipidemia, but that study was discontinued. (Sourced from: https://drugs.ncats.io/drug/QKY617BBX5)

Mechanisms of Action: PPAR-a Agonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: GlaxoSmithKline
Company Location: BRENTFORD MIDDLESEX X0 TW8 9GS
Company CEO: Emma Walmsley
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for GW-590735

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Dyslipidemia

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
PAA20001

P2

Completed

Dyslipidemia

2005-04-01

PAD100958

N/A

Completed

Obesity|Dyslipidemia|Inflammation|Hypercholesterolemia

None

Recent News Events

Date

Type

Title

07/01/2022

PubMed

 Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency.

12/31/2020

PubMed

 Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression.

Did PRYZM just deliver the data you were looking for?
Did you try our Excel download too?

Now that you’ve used PRYZM, we hope you’re able to see for yourself that it was designed and developed by people who actually use this data for a living. By applying next-generation technology for aggregating and curating this info across multiple key sources PRYZM delivering the latest information at your fingertips just the way you need it and with industry leading speed and cost effectiveness.

Our subscribers enjoy unlimited searches and receive this data on their own secure instance so they can overlay any additional internal/proprietary data on top of the search results and blend that data with real-time industry intel from PRYZM. Discover how you can continue to uncover the competitive landscape and drive strategy.

Suggestions