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CYC-116

Alternative Names: cyc-116, cyc116, cyc 116
Latest Update: 2024-04-02
Latest Update Note: PubMed Publication

Product Description

an investigational cancer drug, CYC116, an Aurora kinase inhibitor, in patients with advanced solid tumors. (Sourced from: https://clinicaltrials.gov/ct2/show/NCT00560716)

Mechanisms of Action: AURK Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Cyclacel
Company Location: BERKELEY HEIGHTS NJ 07922
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for CYC-116

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 1: Oncology Solid Tumor Unspecified

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
CYC116-06-01

P1

Terminated

Oncology Solid Tumor Unspecified

2009-01-01

28%

Recent News Events

Date

Type

Title

04/02/2024

PubMed

 Identification and structural characterization of small molecule inhibitors of PINK1.

12/31/2022

PubMed

 The Aurora Kinase Inhibitor CYC116 Promotes the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells.

04/12/2022

PubMed

 A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives.

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