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MK-8141

Alternative Names: mk-8141, mk8141, mk 8141, act-077825
Latest Update: 2015-10-16
Latest Update Note: Clinical Trial Update

Product Description

The renin inhibitor MK-8141 (ACT-077825) demonstrates substantial immunoreactive active renin (ir-AR) increase (sevenfold) without a persistent plasma renin activity (PRA) decrease. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/20705534/)

Mechanisms of Action: Renin Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Merck
Company Location: KENILWORTH NJ 07033
Company CEO: Robert M. Davis
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for MK-8141

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Hypertension

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
MK-8141-006

P2

Completed

Hypertension

2008-06-01

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