Ozmosi | AR-42 Drug Profile

Product Description

AR-42 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (Sourced from: https://clinicaltrials.gov/ct2/show/NCT01129193)

Mechanisms of Action: HDAC6 Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Alison Walker
Company Location:
Company CEO:
Additional Commercial Interests: None

Clinical Description

Countries in Clinic:

Active Clinical Trial Count:

Recent & Upcoming Milestones

Highest Development Phases

Trial ID	Trial	Phase	Trial Status	Disease	Primary Completion Date	Latest Trial Update Date	Data Updated
NCT02569320	OSU-15004	P1	Completed	Multiple Myeloma	2020-11-14	2021-06-16	Patient Enrollment\|Primary Completion Date\|Primary Endpoints\|Start Date\|Study Completion Date\|Treatments\|Trial Status
NCT02282917	14-078H	P1	Terminated	Neuroma, Acoustic\|Neurofibromatoses\|Neurofibromatosis 2\|Neurilemmoma\|Meningioma	2017-05-30	2022-05-12	Primary Endpoints
NCT01129193	OSU-09102	P1	Completed	Multiple Myeloma\|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma\|Lymphoproliferative Disorders\|Adult T-Cell Leukemia-Lymphoma\|Plasmablastic Lymphoma\|Diffuse Large B-Cell Lymphoma\|Prolymphocytic T-Cell Leukemia\|Testicular Cancer\|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma\|Precursor Cell Lymphoblastic Leukemia-Lymphoma\|Immunoblastic Lymphadenopathy\|Lymphomatoid Granulomatosis\|Large-Cell Anaplastic Lymphoma\|Lymphoma, Non-Hodgkin\|Prolymphocytic B-Cell Leukemia\|Large-Cell Immunoblastic Lymphoma\|T-Cell Peripheral Lymphoma\|Lymphocytic Chronic B-Cell Leukemia\|Mycosis Fungoides\|Follicular Lymphoma\|Sezary Syndrome\|Extranodal NK-T-Cell Lymphoma\|Leukemia, Plasma Cell\|Intraocular Lymphoma\|Burkitt Lymphoma\|Chronic Lymphoid Leukemia\|T-Cell Cutaneous Lymphoma\|Prolymphocytic Leukemia\|Mantle-Cell Lymphoma\|B-Cell Marginal Zone Lymphoma\|Waldenstrom Macroglobulinemia	2017-01-07	2019-03-19	Treatments
NCT02795819	MCC-14-10774	P1	Terminated	Sarcoma\|Kidney Diseases\|Renal Cell Carcinoma	2016-11-24	2019-04-04	Patient Enrollment\|Primary Completion Date\|Study Completion Date\|Treatments\|Trial Status
NCT01798901	OSU-11130	P1	Completed	Acute Myeloid Leukemia	2015-02-19	2019-03-19	Treatments

Recent News Events

Date	Type	Title
03/01/2024	PubMed	Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif.
12/19/2023	PubMed	Association Between Clinical Remission of Infantile-Onset Allergic Rhinitis During the School-Age Period and the Type of Housing: A Longitudinal Population-Based Japanese Study.
12/12/2023	PubMed	New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists.

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AR-42

Alternative Names: ar-42, ar42, ar 42 Clinical Status: Inactive Latest Update: 2025-10-07 Latest Update Note: Clinical Trial Update