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Gadolinium

Alternative Names: gadolinium, gadopiclenol, elucirem
Latest Update: 2025-04-17
Latest Update Note: News Article

Product Description

Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands.Ê (Sourced from: https://pubmed.ncbi.nlm.nih.gov/28362042/)

Mechanisms of Action: TRPV4 Inhibitor,TRPM7 Inhibitor,MscL Channel Inhibitor

Novel Mechanism: No

Modality: Diagnostic Agent

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Approved

Approved Countries: Austria | Belgium | Chile | Egypt | France | Indonesia | Malaysia | Russia | Taiwan | United Arab Emirates | United States

Approved Indications: None

Known Adverse Events: None

Company: Guerbet
Company Location:
Company CEO:
Additional Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Gadolinium

Countries in Clinic: Hungary, Italy, Japan, Poland, United States

Active Clinical Trial Count: 9

Highest Development Phases

Phase 3: Brain Cancer|Congenital Heart Defects|Glioma|Other

Phase 2: Brain Diseases|Breast Cancer|Colorectal Cancer|Gastrointestinal Cancer|Lung Cancer|Melanoma|Obstetric Labor, Premature

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
STUDY00017028

P2

Recruiting

Brain Diseases

2026-08-15

IRB #809813

P3

Not yet recruiting

Congenital Heart Defects

2025-06-01

NCT04899908

P2

Recruiting

Colorectal Cancer|Brain Cancer|Melanoma|Breast Cancer|Lung Cancer|Gastrointestinal Cancer

2025-02-01

GDX-44-014 - GDX-101

P3

Recruiting

Other

2024-11-01

66%

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