Drug Search Results

TRV120027

Alternative Names: trv120027
Latest Update: 2023-12-22
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: AT1 Inhibitor

Novel Mechanism: No

Modality: Peptide/Protein

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Trevena
Company Location: CHESTERBROOK PA 19087
Company CEO: Carrie L. Bourdow
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for TRV120027

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Heart Failure

Phase 1: Heart Failure|Kidney Diseases

Trial	Phase	Trial Status	Disease	Primary Completion Date
CP120027.1002	P1	Completed	Kidney Diseases\|Heart Failure	2012-05-01
2010-020376-37	P2	Completed	Heart Failure	2012-04-06
CP120027.2001	P2	Completed	Heart Failure	2012-03-01

Recent News Events

Date	Type	Title
12/22/2023	PubMed	β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage.
07/18/2023	PubMed	The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System.
07/15/2023	PubMed	Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts.

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