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TRV120027

Alternative Names: trv120027
Clinical Status: Inactive
Latest Update: 2023-12-22
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: AT1 Inhibitor

Novel Mechanism: No

Modality: Peptide/Protein

Route of Administration: Intravenous

FDA Designation: *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Trevena
Company Location: CHESTERBROOK PA 19087
Company CEO: Carrie L. Bourdow
Additional Commercial Interests: None

Clinical Description

Countries in Clinic:

Active Clinical Trial Count:

Recent & Upcoming Milestones

Highest Development Phases

Phase 2: Heart Failure

Phase 1: Heart Failure|Kidney Diseases

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

Latest Trial Update Date

Data Updated
CP120027.1002

P1

Completed

Kidney Diseases|Heart Failure

2012-05-01

2019-03-19

Treatments
2010-020376-37

P2

Completed

Heart Failure

2012-04-06

2025-06-08

Treatments
CP120027.2001

P2

Completed

Heart Failure

2012-03-01

2019-03-19

Treatments

Recent News Events

Date

Type

Title

12/22/2023

PubMed

 β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage.

07/18/2023

PubMed

 The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System.

07/15/2023

PubMed

 Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts.

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