Product Description
Aplaviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist with activity against HIV-1. Aplaviroc inhibits HIV-1 entry via CCR5 coreceptor interaction. (Sourced from: https://pubchem.ncbi.nlm.nih.gov/compound/Aplaviroc)
Mechanisms of Action: CCR5 Antagonist
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: N/A
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Company: GSK
Company Location: Europe
Company Founding Year: 2000
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 3: HIV Infections|Acquired Immunodeficiency Syndrome
Phase 2: HIV Infections|Communicable Diseases|Acquired Immunodeficiency Syndrome|Deficiency Diseases
Trial ID |
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|---|
NCT00102778 |
NCT00102778 | P2 |
Terminated |
HIV Infections|Acquired Immunodeficiency Syndrome|Communicable Diseases|Deficiency Diseases |
2007-09-01 |
2019-03-21 |
Treatments |
|
2004-003866-13 |
2004-003866-13 | P2 |
Completed |
HIV Infections |
2006-01-30 |
2022-03-12 |
Treatments |
|
2004-003865-33 |
Phase IIb Dose Selection study for CCR5 | P2 |
Terminated |
HIV Infections |
2006-01-12 |
2022-03-12 |
Treatments |
|
NCT00104429 |
NCT00104429 | P2 |
Terminated |
Deficiency Diseases|HIV Infections|Acquired Immunodeficiency Syndrome|Communicable Diseases |
2006-01-01 |
2019-03-21 |
Treatments |
|
NCT00076284 |
04-I-0087 | P2 |
Completed |
HIV Infections |
None |
2019-03-21 |
Treatments |
|
2005-001246-16 |
2005-001246-16 | P3 |
Completed |
HIV Infections |
2008-02-29 |
2022-03-12 |
Treatments |
|
NCT00297076 |
CCR104456 | P3 |
Terminated |
HIV Infections |
2007-10-01 |
2019-03-21 |
Treatments |
|
NCT00197145 |
CCR102709 | P3 |
Terminated |
Acquired Immunodeficiency Syndrome|HIV Infections |
2007-09-11 |
2019-03-21 |
Treatments |
|
2005-001247-39 |
2005-001247-39 | P3 |
Completed |
HIV Infections |
2007-08-28 |
2022-03-12 |
Treatments |
|
NCT00123890 |
CCR104627 | P3 |
Terminated |
HIV Infections |
2005-10-01 |
2019-03-21 |
Treatments |
|
NCT00197197 |
CCR104458 | P3 |
Terminated |
HIV Infections |
2005-10-01 |
2019-03-21 |
Treatments |
Recent News Events
Date |
Type |
Title |
|---|