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SRT2104

Alternative Names: srt2104
Latest Update: 2024-05-13
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: Sirt1 Activator

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Sirtris
Company Location: CAMBRIDGE MA 02139
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for SRT2104

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Psoriasis|Type 2 Diabetes

Phase 1: Type 2 Diabetes|Chronic Obstructive Pulmonary Disease|Muscular Atrophy|Sepsis|Psoriasis|Colitis, Ulcerative

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
NCT01453491

P1

Completed

Colitis, Ulcerative

2013-03-18

NCT01702493

P1

Completed

Psoriasis

2012-12-05

NCT01154101

P2

Completed

Psoriasis

2011-11-09

NCT01031108

P1

Completed

Type 2 Diabetes

2011-10-12

Recent News Events

Date

Type

Title

05/13/2024

PubMed

 Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway.

03/06/2024

PubMed

 Emerging roles of SIRT1 activator, SRT2104, in disease treatment.

01/01/2024

PubMed

 SIRT1/SREBPs-mediated regulation of lipid metabolism.

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