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Apaziquone

Alternative Names: apaziquone, qapzola
Latest Update: 2023-07-01
Latest Update Note: PubMed Publication

Product Description

Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities.  (Sourced from: https://pubchem.ncbi.nlm.nih.gov/compound/Apaziquone)

Mechanisms of Action: Mitomycin C Analogue

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Spectrum
Company Location: HENDERSON NV 89052
Company CEO: Thomas J. Riga
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Apaziquone

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Bladder Cancer

Phase 2: Bladder Cancer|Urinary Tract Infections|Cystitis|Carcinoma in Situ

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
TURBT

P3

Terminated

Bladder Cancer

2017-03-10

SPI-1011

P3

Terminated

Bladder Cancer

2014-03-01

A9EO9201

P3

Terminated

Bladder Cancer

2013-04-01

SPI-1012

P3

Terminated

Bladder Cancer

2013-04-01

Recent News Events

Date

Type

Title

07/01/2023

PubMed

 Ultimate and Primary Biodegradation of a Range of Nonpolymeric and Polymeric Surfactants in Seawater.

09/01/2022

PubMed

 Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway.

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