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Losmapimod

Alternative Names: losmapimod, gw856553, gw856553x, gs856553
Latest Update: 2024-06-12
Latest Update Note: News Article

Product Description

Mechanisms of Action: MAPK Inhibitor,Immunomodulator

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation:
Fast Track - Muscular Dystrophies|Muscular Dystrophy, Facioscapulohumeral
Orphan Drug - Muscular Dystrophies|Muscular Dystrophy, Facioscapulohumeral *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: GlaxoSmithKline
Company Location: BRENTFORD MIDDLESEX X0 TW8 9GS
Company CEO: Emma Walmsley
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Losmapimod

Countries in Clinic: Canada, Denmark, France, Germany, Italy, Netherlands, Spain, United Kingdom, United States

Active Clinical Trial Count: 9

Highest Development Phases

Phase 3: Muscular Dystrophy, Facioscapulohumeral

Phase 1: Healthy Volunteers

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
FIS-001-2019

P2

Not yet recruiting

Muscular Dystrophy, Facioscapulohumeral

2026-01-01

FIS-002-2019

P2

Not yet recruiting

Muscular Dystrophy, Facioscapulohumeral

2025-10-31

FIS-002-2019 OLE

P2

Active, not recruiting

Muscular Dystrophy, Facioscapulohumeral

2025-10-01

24%
FSHD

P2

Active, not recruiting

Muscular Dystrophy, Facioscapulohumeral

2025-10-01

24%

Recent News Events

Date

Type

Title

06/12/2024

News Article

 Fulcrum Therapeutics to Present at the 31st Annual FSHD Society International Research Congress

06/06/2024

News Article

 Fulcrum Therapeutics to Participate in the Goldman Sachs' 45th Annual Global Healthcare Conference

05/13/2024

News Article

 Fulcrum Therapeutics Enters into a Collaboration and License Agreement with Sanofi for the Development and Commercialization of Losmapimod in Facioscapulohumeral Muscular Dystrophy

05/09/2024

News Article

 Fulcrum Therapeutics to Participate in Upcoming May Conferences

05/01/2024

PubMed

 Safety and efficacy of losmapimod in facioscapulohumeral muscular dystrophy (ReDUX4): a randomised, double-blind, placebo-controlled phase 2b trial.

04/01/2024

PubMed

 Vitamin D3 inhibits p38 MAPK and senescence-associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing.

09/30/2023

PubMed

 Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells.

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