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Linaclotide

Alternative Names: linaclotide, linzess, md-1100 acetate, md-1100, asp-0456, asp0456, asp 0456, Linaclotide Colonic Release-1, Linaclotide Colonic Release-2, md-7246, md7246, md 7246
Latest Update: 2024-06-28
Latest Update Note: News Article

Product Description

Linaclotide is used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It works by increasing intestinal fluid secretion, which helps ease the passage of stools and relieve the symptoms of constipation. (Sourced from: https://www.mayoclinic.org/drugs-supplements/linaclotide-oral-route/description/drg-20075770)

Mechanisms of Action: GUC Agonist

Novel Mechanism: No

Modality: Peptide/Protein

Route of Administration: Oral

FDA Designation: None *

Approval Status: Approved

Approved Countries: Argentina | Australia | Austria | Bangladesh | Belgium | Canada | Croatia | Czech | Denmark | Egypt | Estonia | European Medicines Agency | Finland | Greece | Hong Kong | Hungary | Iceland | Ireland | Italy | Japan | Latvia | Lithuania | Luxembourg | Mexico | Netherlands | New Zealand | Norway | Peru | Poland | Portugal | Saudi Arabia | Slovakia | Spain | Sweden | Switzerland | United Kingdom | United States

Approved Indications: Irritable Bowel Syndrome | Constipation

Known Adverse Events: Abdominal Pain | Pain Unspecified | Diarrhea | Flatulence

Company: Ironwood
Company Location: BOSTON MA 02110
Company CEO: Thomas McCourt
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Linaclotide

Countries in Clinic: Belgium, Bulgaria, Canada, Croatia, Estonia, Germany, Hungary, Israel, Italy, Netherlands, Poland, Puerto Rico, Spain, Ukraine, United Kingdom, United States

Active Clinical Trial Count: 8

Highest Development Phases

Phase 3: Constipation|Irritable Bowel Syndrome

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

M21-862

P2

Recruiting

Constipation

2025-09-30

M21-572

P3

Recruiting

Constipation

2025-08-15

M21-862

P2

Not yet recruiting

Constipation

2024-12-19

M21-572

P3

Recruiting

Constipation

2024-08-30

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