Product Description
Anagrelide is used to decrease the number of platelets (a type of blood cell that is needed to control bleeding) in the blood of patients who have a bone marrow disorder, in which the body makes too many of one or more types of blood cells, such as essential thrombocythemia (condition in which the body makes too many platelets) or polycythemia vera (condition in which the body makes too many red blood cells and sometimes too many platelets). Anagrelide is in a class of medications called platelet-reducing agents. It works by slowing the production of platelets in the body. (Sourced from: https://medlineplus.gov/druginfo/meds/a601020.html)
Mechanisms of Action: PLA2 Inhibitor,PDE3 Inhibitor
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Approved
Approved Countries: Argentina | Australia | Austria | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | Croatia | Cyprus | Czech | Denmark | Egypt | Estonia | European Medicines Agency | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | Indonesia | Ireland | Israel | Italy | Japan | Korea | Latvia | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Netherlands | New Zealand | Norway | Pakistan | Philippines | Poland | Portugal | Romania | Russia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sweden | Switzerland | Taiwan | Thailand | Turkey | Ukraine | United Kingdom | United States
Approved Indications: Thrombosis | Oncology Unspecified
Known Adverse Events: Tachycardia | Abdominal Pain | Back Pain | Chest Pain | Dizziness | Headache | Pain Unspecified | Paresthesia | Pruritus | Dyspnea | Anorexia | Asthenia | Diarrhea | Dyspepsia | Edema | Flatulence
Company: Takeda
Company Location: TOKYO M0 103-8668
Company CEO:
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Canada, China, Hong Kong, Japan, Korea, Singapore, Taiwan, United States
Active Clinical Trial Count: 3
Highest Development Phases
Phase 3: Thrombocythemia, Essential|Thrombocytosis
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
---|---|---|---|---|---|
SURPASS ET | P3 |
Active, not recruiting |
Thrombocytosis|Thrombocythemia, Essential |
2024-11-30 |
64% |
JapicCTI-205314 | P3 |
Planned |
Thrombocythemia, Essential |
2022-06-30 |
|
jRCT2080225218 | P3 |
Recruiting |
Thrombocythemia, Essential |
None |