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Amuvatinib

Alternative Names: amuvatinib, mp-470, mp470
Latest Update: 2024-08-02
Latest Update Note: Clinical Trial Update

Product Description

Amuvatinib is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity. (Sourced from: https://pubchem.ncbi.nlm.nih.gov/compound/Amuvatinib)

Mechanisms of Action: RTK Inhibitor,C-Met Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Intravenous,Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Astex
Company Location: DUBLIN CA 94568
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Amuvatinib

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Small Cell Lung Cancer

Phase 1: Oncology Solid Tumor Unspecified

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
ESCAPE

P2

Completed

Small Cell Lung Cancer

2012-05-01

SGI-0470-02

P1

Completed

Oncology Solid Tumor Unspecified

2009-12-01

SGI-0470-01

P1

Completed

Oncology Solid Tumor Unspecified

2008-12-01

SUPERGEN-SGI-0470-01

N/A

Terminated

Lymphoma

2008-12-01

Recent News Events

Date

Type

Title

10/01/2023

PubMed

 Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations.

09/22/2023

PubMed

 Identification of a cancer-associated fibroblast classifier for predicting prognosis and therapeutic response in lung squamous cell carcinoma.

07/01/2023

PubMed

 Nivolumab and ipilimumab with concurrent stereotactic radiosurgery for intracranial metastases from non-small cell lung cancer: analysis of the safety cohort for non-randomized, open-label, phase I/II trial.

03/18/2020

News Article

 Legion Healthcare Partners adds Expert in Immuno-RT to its Scientific Advisory Board

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