Product Description
Mechanisms of Action: PDK Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: Colombia | India | Peru | Taiwan | United Kingdom
Approved Indications: None
Known Adverse Events: None
Company: Saol Therapeutics
Company Location:
Company CEO:
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 4: Insulin Resistance
Phase 3: Acidosis, Lactic|Pyruvate Dehydrogenase Complex Deficiency Disease
Phase 2: Glioblastoma|Glioma|Acidosis, Lactic|Head and Neck Cancer|Healthy Volunteers|Breast Cancer|Squamous Cell Carcinoma|MELAS Syndrome|Non-Small-Cell Lung Cancer|Multiple Myeloma
Phase 1: Tumor Lysis Syndrome|Potassium Deficiency|Brain Cancer|Protein Deficiency|Liver Cancer|Glioblastoma|Hypoglycemia|Healthy Volunteers|Type 1 Diabetes|Lung Cancer|Breast Cancer|Evans Syndrome|Pyruvate Dehydrogenase Complex Deficiency Disease|Deficiency Diseases|Mitochondrial Diseases|Acidosis, Lactic|Brain Death|MELAS Syndrome|Hypertension, Pulmonary|Familial Primary Pulmonary Hypertension|Head and Neck Cancer|Hyperglycemia|Brain Injuries
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| HSC-MS-24-0756 | N/A |
Not yet recruiting |
Generalized anxiety disorder |
2027-06-30 |
|
| DCA | P2 |
Not yet recruiting |
Glioblastoma |
2026-12-30 |
|
| ACTRN12623001164684 | N/A |
Recruiting |
Nose Cancer |
2026-10-30 |
|
| IRB202101509 | P2 |
Recruiting |
Glioblastoma |
2026-07-01 |
|
| NCT05317455 | P1 |
Recruiting |
Hypoglycemia|Type 1 Diabetes |
2026-05-01 |
|
| DCA/PDCD | P3 |
Active, not recruiting |
Pyruvate Dehydrogenase Complex Deficiency Disease |
2025-08-27 |
4% |
| Application of a new portable ultrasonic diagnostic instrument | N/A |
Recruiting |
Other |
2025-07-31 |
|
| NC002 | N/A |
Recruiting |
General Diabetes |
2024-03-31 |
|
| EPiC | N/A |
Completed |
Endometriosis |
2021-09-30 |
|
| SRIC-CA | N/A |
Completed |
Brain Ischemia |
2021-07-19 |
|
| NCT03356457 | P1 |
Completed |
Hypoglycemia|Hyperglycemia|Brain Injuries |
2019-03-20 |
|
| ACTRN12617000555358 | N/A |
Terminated |
Hypoglycemia|Type 1 Diabetes|Type 2 Diabetes |
2017-07-31 |
|
| CARBEX | P4 |
Unknown status |
Insulin Resistance |
2017-06-01 |
|
| IRB201500995 - N | P1 |
Completed |
Mitochondrial Diseases|Deficiency Diseases|Pyruvate Dehydrogenase Complex Deficiency Disease |
2017-05-30 |
|
| RIPCA | N/A |
Completed |
Brain Ischemia |
2017-05-01 |
|
| IRB-18245 | P1 |
Completed |
Head and Neck Cancer |
2015-02-01 |
|
| DCA 2010 | P2 |
Completed |
Squamous Cell Carcinoma|Head and Neck Cancer |
2014-08-01 |
|
| CTSI | P1 |
Completed |
Brain Cancer|Glioblastoma |
2014-03-01 |
|
| DCA 20001 | P1 |
Completed |
Familial Primary Pulmonary Hypertension|Hypertension, Pulmonary |
2013-09-01 |
|
| PBT | P1 |
Completed |
Healthy Volunteers |
2013-07-01 |
|
| DCA | P1 |
Completed |
Tumor Lysis Syndrome|MELAS Syndrome|Brain Death|Protein Deficiency|Liver Cancer|Brain Cancer|Lung Cancer|Breast Cancer|Acidosis, Lactic|Evans Syndrome|Potassium Deficiency |
2013-03-01 |
|
| 14617-CP-004 | N/A |
Completed |
Acidosis, Lactic |
2012-11-01 |
|
| IRB#107-10 | P2 |
Completed |
Healthy Volunteers |
2012-10-01 |
|
| H10-02551 | N/A |
Unknown status |
Type 2 Diabetes |
2012-06-01 |
|
| 14617-CP-001 | N/A |
Terminated |
Healthy Volunteers |
2012-01-01 |